Advisor, Medicinal Chemistry

Role Summary

Advisor, Medicinal Chemistry role within Lilly’s Medicinal Chemistry group in South San Francisco, CA. Responsible for advancing synthetic chemistry and drug discovery programs from early lead generation to identification of clinical candidates.

Responsibilities

• Apply and create innovative synthetic methodologies to enable novel small molecule design, solve synthetic challenges, and inform fast-paced SAR iterations through proposal and execution of synthetic routes in the laboratory
• Design and synthesize novel small molecules; optimize lead compounds by improving potency, selectivity, physicochemical properties, and DMPK to meet target product profiles
• Leverage structure-based drug design technologies; collaborate with computational chemistry and biophysics to characterize protein-ligand interactions and support de novo molecular design
• Collaborate across fields; interact with pharmacology, translational science, ADME, and toxicology to address program needs and provide Medicinal Chemistry perspectives

Qualifications

• PhD in organic chemistry
• Master‚Äôs degree with 7‚Äì10+ years of experience

Skills

• Strong Synthetic Organic Chemistry skills with extensive experience in modern synthetic methodologies, experimental work, isolation/purification, and structural analysis of synthetic organic molecules
• Ability to stay current with literature on chemical transformations
• Scientific creativity and ability to work independently, solving problems through careful experimental design, data analysis, and mechanistic insight
• Proven track record of scientific contributions including peer-reviewed publications, patents, and presentations
• Excellent English communication skills; ability to collaborate effectively in a multidisciplinary, international environment
• Proficient with Microsoft Office and scientific data tools (e.g., SciFinder, Reaxys) to identify literature
• Strong work ethic, scientific curiosity, and proactive attitude