At Lilly, we unite caring with discovery to make life better for people around the world.

We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Position Overview

Eli Lilly and Company is seeking a highly motivated and skilled Beamline Engineer to join the Structural Biology team within Lilly Small Molecule Discovery (LSMD), part of Lilly Research Laboratories. LSMD is a dynamic and diverse organization committed to advancing drug discovery through innovation and scientific excellence. The successful candidate will join the LRL-CAT beamline, which operates a state-of-the-art synchrotron beamline at the Advanced Photon Source (APS) for macromolecular crystallography experiments that support structure-based drug design (SBDD) efforts across Lilly’s research portfolio.

As a Beamline Engineer, you will play a critical role in the operation, maintenance, and evolution of the LRL-CAT beamline. You will work collaboratively with structural biologists, engineers, and external partners to ensure high-quality data collection and delivery from challenging drug discovery targets. This role is hands-on, technical, and vital to our mission to discover and develop innovative therapies for patients.

Do you have experience leading and collaborating in a team environment? Consider joining Lilly today and help to make a difference in our purpose and communities we serve!

Location

Advanced Photon Source, Argonne National Laboratory, Lemont, IL

Responsibilities

• Provide Eli Lilly and Company with high-quality X-ray diffraction data to support structure-based drug design.
• Manage samples from Lilly for both on-site (LRL-CAT) and off-site data collection.
• Assist with off-site data collection.
• Set up, align, and operate the LRL-CAT beamline for routine data collection, process diffraction data, and deliver results to users; troubleshoot and resolve issues to ensure continuous operation.
• Oversee automated data collection at LRL-CAT and collect or reprocess datasets as needed.
• Collaborate with and maintain strong working relationships with internal and external partners.
• Maintain and upgrade beamline components, including but not limited to, focusing mirrors, X-ray beam monitor amplifiers, sample cryostream, water-cooling and LN₂ infrastructure, Venturi system, and dehumidifiers. Share responsibility for the maintenance of high-precision beamline motors, vacuum systems, and safety.
• Coordinate with vendors for the maintenance and repair of specialized beamline equipment, including those listed above.
• Co-maintain the data processing pipeline software.
• Manage proprietary and General User samples and collect data for these users.
• Support the maintenance and optimization of beamline control software.
• Design, procure, install, and commission beamline upgrades.
• Coordinate with Advanced Photon Source staff to support daily beamline operations.

Basic Requirements

• Ph.D. in Engineering.
• At least 1 year of experience working as an engineer at a macromolecular crystallography synchrotron beamline.
• At least 3 years of technical experience at a synchrotron beamline.

Additional Skills

• Experience in operating and maintaining automated sample handlers typically used in Macromolecular Crystallography beamlines.
• Knowledge of machining capabilities, motor motion controls, and electronic components, as well as computers and computer networks.
• Knowledge of macromolecular X-ray crystallography, including crystal growth, mounting, data collection, and processing.
• Skills in troubleshooting, diagnostics, and independent judgment in technical problem-solving.
• Ability to rapidly learn in an environment that requires multi-disciplinary skills.
• Expertise in the maintenance and diagnostic techniques applicable to synchrotron beamline instrumentation and operations.
• Experience supporting and operating complex and large-scale instrumentation in a scientific user environment.
• Experience with EPICS, CCP4 suite, common MX data processing software, Linux shell environments, and Linux distributions.
• Proficiency with Python and Oracle-based LIMS.
• Experience interacting with scientific staff and beamline users.
• Experience with computer networking.
• Highly self-motivated and proactive.
• Demonstrated excellent communication and interpersonal skills.

Additional Information

• Travel: Occasional domestic and potential international travel.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Employee Resource Groups (ERGs)

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Compensation and Benefits

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$123,750 - $198,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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