At Lilly, we unite caring with discovery to make life better for people around the world.

We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly Gene Therapy, we are developing a pipeline of gene therapies to slow or stop the underlying disease process for patients with genetic disorders. We are leveraging recent breakthroughs in human genetics that point to potential disease-modifying targets for diseases. Our programs utilize a precision medicine approach targeting patient populations with urgent unmet needs, where there are currently no available therapies that modify the progressive course of their disorders.

Meet Your Future Team

The Analytical Development team is a tight-knit group of energetic, smart, fun, and motivated individuals. We work closely on Lilly Gene Therapy’s Adeno-Associated Virus (AAV)-based gene therapy programs to progress our mission of curing disease. We are responsible for developing and running robust and innovative analytical methods to support internal and external manufacturing processes, while also staying on the cutting-edge of industry standards.

While much of the day-to-day operations require wet-lab work, our team focuses on not only building everyone’s technical expertise but also fostering an environment for career growth as scientists in the biopharmaceutical industry. As analytical development relates to quality, process development, preclinical and clinical R&D, manufacturing, and regulatory functions, there is opportunity for exposure to the whole scope of biopharmaceutical industry processes. We are seeking a motivated research associate who can take on ownership of established characterization assays as well as contribute to the development of new cutting-edge assays for testing AAVs.

Position Overview

The Advisor, Analytical Development will be responsible for development of novel analytical techniques for characterization of gene therapy drugs, as well as assisting with the routine testing to support lot releases, process development and stability studies. The Scientist will interact with other departments and coordinate efforts across departments as well as lead analytical projects. The ideal candidate will have a track record of molecular biology, analytical chemistry, and developing assays.

Responsibilities

• In this position, the individual will perform assays such as LC-MS, HPLC, AUC, UV, etc. to support gene therapy projects. This includes preparing samples, setting up and running the instruments, and analyzing data.
• Independently develop, establish and test new methodologies used for the characterization of gene therapy drugs.
• Perform analytical methods to support AAV manufacturing and process development.
• Analyze, document, and report data.
• Support the existing development team, transfer and qualification/validation activities.
• Act as company liaison with CMOs to coordinate in method development and method transfer across various CMO/CRO sites as needed.
• Author technical reports and SOPs.
• Communicate data within the group as well as across functions.
• Record and document experiments, analyze data and offer conclusions obtained from sample testing.
• Broadly contribute to strategic thinking and development or experiments that help characterize novel gene therapies.

Basic Requirements

• Ph.D in Biophysics, Biochemistry, Molecular Biology, or related scientific field with 1+ years of experience with mass spectrometry.

Additional Skills/Preferences

• HPLC based separation techniques is desired
• Prior working knowledge and experience with AAVs and gene therapy.
• Prior experience with oligonucleotide characterization is a plus.
• Preferred having a good foundation in general scientific practice and the principles and concepts of a relevant scientific field of study.
• Expertise in creative thinking and multitasking with strong communication skills and comfort in a fast-paced, work environment.
• Good interpersonal, verbal, and written skills.
• Motivated, detail-oriented, quick learner.
• Understanding of analytical method lifecycle of development, qualification, validation, and documentation is a plus.
• Strong organizational and problem-solving skills and attention to detail.
• Ability to work independently and in a dynamic team environment.
• Excellent verbal and written communication skills.

Additional Information

• 5-10% Travel
• Position Location: Eli Lilly and Company, Boston

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$133,500 - $217,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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