ADME Project Leadership for Genetic Medicines

Role Summary

ADME Project Leadership for Genetic Medicines. Join Lilly’s diverse ADME team focused on discovery and clinical development of genetic medicines, including siRNAs, ASOs, mRNAs, gene editing, and gene therapy. Lead multidisciplinary efforts to advance next-generation genetic therapies from discovery through preclinical and clinical development, collaborating with biologists, chemists, engineers, and other R&D functions. This full-time role is based in Boston, MA.

Responsibilities

• Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
• Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
• Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies
• Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
• Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
• Build relationships through coaching and mentorship with fellow scientists at all levels
• Possess excellent written and verbal technical communication and the ability to constructively lead, guide and influence teams

Qualifications

• Required: Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field
• Required: Zero to five years of experience as a scientist in a pharmaceutical and/or biotechnology company
• Preferred: Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeutics
• Preferred: PK/PD modeling and simulation experience
• Preferred: Targeted delivery and biodistribution of oligonucleotides and/or gene therapies experience
• Preferred: Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology

Education

• Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field

Skills

• Strong working knowledge of fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles—especially related to novel genetic medicine modalities
• High learning agility and ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel molecules
• Understanding of pharmaceutical regulatory guidance and expectations
• Ability to interpret diverse data sets (in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and ADME/DMPK characteristics