ADME Project Leadership for Genetic Medicines
Eli Lilly and Company
3 months ago
Remote friendly (Boston, MA)
United States
$156,750 - $250,800 USD yearly
Clinical Research and Development
A High-quality Candidate Will Demonstrate The Following
- High learning agility and a keen ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel molecules
- Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles—especially as they relate to novel genetic medicine therapeutic modalities
- Understanding of pharmaceutical regulatory guidance and expectations
- Agile interrogation of diverse data (in silico, in vitro, in vivo) to interpret complex data sets and derive mechanistic understanding of drug action and ADME/DMPK characteristics
Lilly seeks a skilled ADME / DMPK scientist who will:
- Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
- Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
- Integrate ADME, PK, and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies
- Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
- Lead preparation of ADME portions of regulatory communications and documents for clinical development, new drug applications, and line extensions; interact with global regulatory authorities
- Build relationships through coaching and mentorship with fellow scientists at all levels
- Possess excellent written and verbal technical communication and the ability to constructively lead, guide, and influence teams
Basic Requirements
- Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or related scientific field
- Zero to five years of experience as a scientist in a pharmaceutical and/or biotechnology company
Additional Skills/Preferences
- Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeutics
- Experience with PK/PD modeling and simulation
- Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
- Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology
Benefits/Compensation (as stated)
- This is a full-time position located in Boston, MA
- Anticipated wage: $156,750 - $250,800
- Full-time employees also may be eligible for a company bonus (depending, in part, on company and individual performance)
- Comprehensive benefit program (including eligibility for 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance, time off/leave benefits, and well-being benefits)
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation
- High learning agility and a keen ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel molecules
- Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles—especially as they relate to novel genetic medicine therapeutic modalities
- Understanding of pharmaceutical regulatory guidance and expectations
- Agile interrogation of diverse data (in silico, in vitro, in vivo) to interpret complex data sets and derive mechanistic understanding of drug action and ADME/DMPK characteristics
Lilly seeks a skilled ADME / DMPK scientist who will:
- Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
- Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
- Integrate ADME, PK, and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies
- Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
- Lead preparation of ADME portions of regulatory communications and documents for clinical development, new drug applications, and line extensions; interact with global regulatory authorities
- Build relationships through coaching and mentorship with fellow scientists at all levels
- Possess excellent written and verbal technical communication and the ability to constructively lead, guide, and influence teams
Basic Requirements
- Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or related scientific field
- Zero to five years of experience as a scientist in a pharmaceutical and/or biotechnology company
Additional Skills/Preferences
- Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeutics
- Experience with PK/PD modeling and simulation
- Experience with targeted delivery and biodistribution of oligonucleotides and/or gene therapies
- Understanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodology
Benefits/Compensation (as stated)
- This is a full-time position located in Boston, MA
- Anticipated wage: $156,750 - $250,800
- Full-time employees also may be eligible for a company bonus (depending, in part, on company and individual performance)
- Comprehensive benefit program (including eligibility for 401(k), pension, vacation, medical/dental/vision/prescription benefits, flexible benefits, life insurance, time off/leave benefits, and well-being benefits)
Application Instructions
- If you require accommodation to submit a resume, complete the workplace accommodation request form: https://careers.lilly.com/us/en/workplace-accommodation