2026 U.S. Summer Internship Program: PBPK (Physiologically Based Pharmacokinetic Modeling) Intern

Role Summary

2026 U.S. Summer Internship Program: PBPK (Physiologically Based Pharmacokinetic Modeling) Intern

Responsibilities

• Sharpen skills in PBPK modeling software like Simcyp and GastroPlus
• Collaborate with DMPK&M colleagues to identify data requirements for model development, and strategies for model application and use
• Apply modeling for prediction of drug-drug interactions (DDI)

Qualifications

• Must be enrolled in a Ph.D program in drug metabolism and pharmacokinetics, quantitative pharmacology, clinical pharmacology, toxicology, pharmacometrics, biomedical engineering, pharmaceutical sciences or another related field.
• Must have prior experience with PBPK modeling (Simcyp preferred).
• Be acquainted with standard techniques of model training, validation, and characterization.
• Strong training and understanding of the concepts of drug metabolism and pharmacokinetics of small molecules, biochemical aspects of drug metabolism enzymes and transporters, and various in vitro assays conducted to assess DDI potential
• Track record of publication and / or conference presentations
• Exceptional interpersonal, verbal communication and writing skills
• Good organizational and planning skills
• Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity
• Strong quantitative, analytical and problem-solving skills
• Global mindset to grow in a diverse work environment

Skills

• PBPK modeling
• Data analysis
• Communication
• Team collaboration
• Model training and validation

Education

• Ph.D program in relevant field (see Qualifications)

Additional Requirements

• This position will be hybrid (1-3 days in office), out of the Cambridge, MA location
• Internship duration and start dates: 10-12 weeks with possible start windows